Omics data are usefull to monitor the immune response to pathogens in all infectious diseases and their related treatments. It is used to uncover how pathogens infect host cells and elicit immune responses. Link the host immune response to infection recovery or severity.
Immune repertoire analysis can be used to evaluate on one hand, a candidate vaccine’s capacity to trigger a protective immune response.
Immunity against pathogens
The adaptive immune response induced by an infection are studied by analyzing the diversity of TCR and BCR in the infected organism. In particular, NGS based immune repertoire makes it possible to describe, at an unprecedented level of detail, the structure of the B and T repertoires after immunization or infection. These approaches can be used to decipher the basics of immune-induced memory in the organism.
Viral Drug Resistance Mutation identification
The emergence of drug resistance is an important factor in the management of infections. Genotypic drug resistance testing with omics methods can detect drug-resistant mutations (DRMs) present at a very fine level.
Omics data have used to identified viral genomic regions known to develop resistance mutations. I has been used for the clinical management of several viral infections, including human immunodeficiency virus (HIV), cytomegalovirus (CMV), hepatitis B, hepatitis C, and influenza and it is conceivable that these methods will be applicable for all others microorganisms.