Our different omics solutions have the potential to boost research programs. Several clinical fields can benefit from our immune expertise, including fundamental and translational research, such as immuno-oncology, infectious diseases, autoimmune and inflammatory diseases.
Look how Parean biotechnologies inspires researchers to drive discoveries.
Oncology and Immunotherapy
Immune system is a key component of tumor growth, metastasis dissemination and response to treatment.
Decipher intratumoral heterogeneity and track transcriptomic modulators, within tumors and across cancer types.
Uncover the influence of tumor immune infiltration. Identify diverse transcriptomic phenotypes driving the therapeutic response.
Improve immunotherapies response by characterizing immune cell modulation in tumor progression. Define immune repertoire of infiltrating or circulating immune cells. Predict and monitor immune-related adverse events.
Discover new targets, explore how therapeutics modulate cell populations, and understand resistance mechanisms.
Omics data are useful to monitor the immune response to pathogens in all infectious diseases and related treatments. It is used to uncover how pathogens infect host cells and elicit immune responses. Link the host immune response to infection recovery or severity.
Immune repertoire analysis can be used to evaluate a candidate vaccine’s capacity to trigger a protective immune response.
Immunity against pathogens
The adaptive immune response induced by an infection is studied by analyzing the diversity of TCR and BCR in the infected organism. In particular, NGS based immune repertoire makes it possible to describe, at an unprecedented level of details, the structure of B and T repertoires after immunization or infection. These approaches can be used to decipher immune-induced memory.
Viral Drug Resistance Mutation identification
The emergence of drug resistance is an important factor in the management of infections. Genotypic drug resistance testing with omics methods can detect drug-resistant mutations (DRMs) in depth.
Gain a richer understanding of the nervous system and accelerate the discovery of fundamental biology driving multifactorial neurodegenerative diseases (Alzheimer, Parkinson, SLA, ..).
Build a complete picture of neurodegenerative diseases in multiple dimensions. Improve your understanding on how pathological features affect the surrounding microenvironment and immune cell contribution.
Discover the cellular and molecular foundations of immune related psychiatric disorders. Characterize disease-associated cellular phenotypes and uncover novel pathological effects. Explore the regulatory landscape of immune cells and identify transcriptomic signature of discrete cell types.
Auto-Immunity / Inflammation
Auto-immunity and inflammation components are present in various diseases, and requires translational research programs.
Identify new cell phenotypes
From flow cytometry to transcriptomic single-cell analysis, you can detect novel or rare sub-populations within each specific type of sample.
Identify antigen specificity
Organ-specific inflammatory disease are suspected to be driven by auto-antigens. Understand how antigen are recognized by the immune repertoire is crucial to investigate these diseases.
Assess new biomarkers for diagnosis and/or prognosis
Biomarkers are key to refine diagnosis and identify subgroups of patients, especially those at increased risk for disease progression and/or to evaluate treatments response.