Oncology and Immunotherapy

Immune system is a key component of tumor growth, metastasis dissemination and response to treatment.

Tumor Heterogeneity

Decipher intratumoral heterogeneity and track transcriptomic modulators, within tumors and across cancer types.

Tumor Microenvironment

Uncover the influence of tumor immune infiltration. Identify diverse transcriptomic phenotypes driving the therapeutic response.

Immuno-oncology

Improve immunotherapies response by characterizing immune cell modulation in tumor progression. Define immune repertoire of infiltrating or circulating immune cells. Predict and monitor immune-related adverse events.

Therapeutic Development

Discover new targets, explore how therapeutics modulate cell populations, and understand resistance mechanisms.

Infectious diseases

Omics data are useful to monitor the immune response to pathogens in all infectious diseases and related treatments. It is used to uncover how pathogens infect host cells and elicit immune responses. Link the host immune response to infection recovery or severity.

Immune repertoire analysis can be used to evaluate a candidate vaccine’s capacity to trigger a protective immune response.

Immunity against pathogens

The adaptive immune response induced by an infection is studied by analyzing the diversity of TCR and BCR in the infected organism. In particular, NGS based immune repertoire makes it possible to describe, at an unprecedented level of details, the structure of B and T repertoires after immunization or infection. These approaches can be used to decipher immune-induced memory.

Viral Drug Resistance Mutation identification

The emergence of drug resistance is an important factor in the management of infections. Genotypic drug resistance testing with omics methods can detect drug-resistant mutations (DRMs) in depth.

Neuroscience

Gain a richer understanding of the nervous system and accelerate the discovery of fundamental biology driving multifactorial neurodegenerative diseases (Alzheimer, Parkinson, SLA, ..).

Neurodegenerative Disease

Build a complete picture of neurodegenerative diseases in multiple dimensions. Improve your understanding on how pathological features affect the surrounding microenvironment and immune cell contribution.

Psychiatric Disorders

Discover the cellular and molecular foundations of immune related psychiatric disorders. Characterize disease-associated cellular phenotypes and uncover novel pathological effects. Explore the regulatory landscape of immune cells and identify transcriptomic signature of discrete cell types.

Auto-Immunity / Inflammation

Auto-immunity and inflammation components are present in various diseases, and requires translational research programs.

Identify new cell phenotypes

From flow cytometry to transcriptomic single-cell analysis, you can detect novel or rare sub-populations within each specific type of sample.

Identify antigen specificity

Organ-specific inflammatory disease are suspected to be driven by auto-antigens. Understand how antigen are recognized by the immune repertoire is crucial to investigate these diseases.

Assess new biomarkers for diagnosis and/or prognosis

Biomarkers are key to refine diagnosis and identify subgroups of patients, especially those at increased risk for disease progression and/or to evaluate treatments​ response.